Bioactive Small Molecules
AdipoGen Pyridoxal 5'-phosphate monohydrate (5 g)
Chemical. CAS: 41468-25-1. Formula: C8H10NO6P . H2O. MW: 265.16. The enzyme cofactor Pyridoxal-5‘-phosphate monohydrate is a vitamin B6 metabolite that can modify lysyl and valyl residues in proteins. It acts as a coenzyme in transamination reactions by forming a Schiff-base linkage with lysine groups on aminotransferase. Also serves as a coenzyme in some decarboxylation and deamination reactions. It has the ability to inhibit purinergic receptors and intracellular influx of Ca2+. Pyridoxal-5‘-phosphate monohydrate can modify peptides and suppress their precursor ionization efficiency. Research shows that pyridoxal-5‘-phosphate-dependent enzymes can be inhibited by cycloserine.
Cayman Chemical ANTIBODY RO5166017 10mg
A TAAR1 agonist; binds to TAAR1 (Kis = 31, 24, 1.9, and 2.7 nM in HEK293 cells expressing the recombinant human, cynomolgus monkey, mouse, or rat enzyme, respectively) and is >15-fold selective for TAAR1 over a panel of 123 receptors, ion channels, and transporters at 10 µM; induces cAMP production in HEK293 cells expressing human, cynomolgus monkey, mouse, or rat TAAR1 (EC50s = 55, 97, 3.3, and 14 nM, respectively); reduces the frequency of neuronal firing in mouse VTA and DRN slices (IC50s = 1.73 and 2.99 nM, respectively); inhibits stress-induced hyperthermia, as well as reduces cocaine-induced hyperlocomotion, in mice; impairs expression of cocaine-induced place preference in rats
Cayman Chemical ANTIBODY CV-6209-d5 500UG
An internal standard for the quantification of CV-6209 by GC- or LC-MS
Medchemexpress LLC 2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid | 2231744-57-1 | 95.0% | 238.71 | 50 MG
2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid is a PROTAC linker utilized in PROTAC SMARCA2/4-degrader-34 (HY-169279). It is intended for research use only and is not for patient use. This compound has been referenced in studies exploring small molecule degraders to enhance chemotherapy efficacy.
- PROTAC linker
- For research use only
- Not sold to patients
- Referenced in studies on chemotherapy efficacy
Cayman Chemical ANTIBODY MKC-3946 5mg
An inhibitor of IRE1α; inhibits ER stress induced XBP1 splicing and reduces expression of the XBP1 target genes SEC61A1, p58IPK, and ERdj4 in RPMI 8226 cells; cytotoxic to multiple myeloma cell lines but has no effect on normal mononuclear cells; reduces tumor growth and XBP1 splicing in an RPMI 8226 mouse xenograft model (100 mg/kg)
Cayman Chemical 1Stearoyl2LInoleoyl3Oleo 5mg
A triacylglycerol; has been found in poppy seed, maize, and evening primrose oils
Medchemexpress LLC Denfivontinib | 1457983-28-6 | MFCD28167815 | 98.0% | 521.41 g/mol | C25H25BrN6O2 | 1MG
Denfivontinib (G-749) is a small-molecule, ATP-competitive FLT3 inhibitor used in preclinical research. It features a brominated pyrido[4,3-d]pyrimidinone core and has demonstrated antitumor activity in FLT3-driven models. The compound is supplied as a dry powder for laboratory studies; consult safety documents before handling.
Medchemexpress LLC Becotatug (Synonyms: JMT-101) 5mg
Becotatug (JMT-101) is an IgG1 antibody targeting EGFR that can also be conjugated to Afatinib (HY-10261) and Osimertinib (HY-15772) as a synthetic ADC.
Medchemexpress LLC MKA031 | 2951012-00-1 | 98.7% | 403.46 | 5 MG
MKA031 (compound 6y) is a non-competitive MIF inhibitor with an IC50 value of 1.7 μM. It interferes with MIF/AIF interaction, MIF nuclear translocation, and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced dependent cell death. MKA031 can be utilized in the study of chronic hepatitis C virus infection.
- Interferes with MIF/AIF interaction
- Blocks MIF nuclear translocation
- Prevents N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced dependent cell death
- Protects genomic DNA by blocking the recruitment of MIF to AIF
Medchemexpress LLC DMA-135 hydrochloride | 2237925-62-9 | MFCD34676484 | 98.0% | 359.81 g/mol | C16H18ClN7O | 5 MG
DMA-135 hydrochloride is the hydrochloride salt of a small-molecule that targets the internal ribosome entry site (IRES) of enterovirus 71 (EV71). It binds the SLII RNA domain with moderate affinity (KD ≈ 520 nM) and suppresses IRES-dependent translation and viral replication in cell-based studies, making it suitable as a research reagent for antiviral and RNA-ligand interaction studies.
- Hydrochloride salt of an EV71 IRES-targeting small molecule.
- Binds SLII RNA domain with KD ≈ 520 nM.
- Inhibits IRES-dependent translation and replication in cell assays.
- High purity (~98.0% by HPLC).
- Available as solid and as 10 mM solution in DMSO for assays.
- Molecular formula C16H18ClN7O; molecular weight 359.81 g/mol.
Cayman Chemical ANTIBODY OncrasIn-1 100mg
An anticancer agent; has activity against lung cancer cells expressing constitutively active K-Ras (IC50s = 0.25, 1, 1.58, and 0.11 for H460, H2122, A549, and H2887 cells, respectively); induces nuclear aggregation of PKCι and apoptosis in T29Kt1 and H460 cells; reduces tumor volume and increases survival time in an H460 mouse xenograft model at 100 mg/kg per day
Medchemexpress LLC 1,3-Dithiane | 505-23-7 | 120.24 | 5 G
1,3-Dithiane is a protected formaldehyde anion equivalent and a sulfur-containing Maillard reaction product found in cooked beef extracts. It is a potent mutagenic agent and can also be used as a useful marker synthon.
- Protected formaldehyde anion equivalent
- Sulfur-containing Maillard reaction product
- Found in cooked beef extracts
- Functions as a potent mutagenic agent
- Used as a useful marker synthon
- Exhibits direct mutagenicity in bacterial assays
- Induces sister chromatid exchange frequency in cell assays
Medchemexpress LLC TNIK-IN-8 | 3068941-89-6 | 98.8% | 385.43 | 1 ML
TNIK-IN-8 (Compound 35b) is a potent, orally active TNKI inhibitor with an IC50 value of 6 nM. It exhibits antitumor activity.
- Potent, orally active TNKI inhibitor
- IC50 value of 6 nM
- Exhibits antitumor activity
- Inhibits cell growth in human DLD-1 cells with an IC50 of 21.47 μM
- Inhibits cell growth in human HCT-116 cells with an IC50 of 2.11 μM
- Inhibits cell growth in human HT-29 cells with an IC50 of 13.6 μM
Medchemexpress LLC HY-P2373 5mg Medchemexpress, Nattokinase CAS:133876-92-3 Purity:>98%
Medchemexpress, HY-P2373 5mg Nattokinase CAS:133876-92-3 Nattokinase is a potent fibrinolytic enzyme. Nattokinase can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Nattokinase can be used for the research of cardiovascular diseases. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.